Cannabis and Glutathione levels.

So, there is all this hype about Cannabis and it’s constituents. The word is always positive about health and wellness.
I’d like to say, there are no downsides to CBD and THC and all of the other key players in the health benefits that people talk about. I’m not gonna.

I’m gonna show you the downside instead, that is very significant to your health.

Oxidative stress produced by marijuana smoke. An adverse effect enhanced by cannabinoids.

“In contrast, exposure to smoke from MJ containing 0% Delta9-THC produced no increase in ROS despite a 70% decline in glutathione levels. Smoke from MJ containing 1.77% Delta9-THC stimulated intermediate levels of ROS. A brief, 30-min exposure to MJ smoke, regardless of the Delta9-THC content, also induced necrotic cell death that increased steadily up to 48 h of observation. MJ smoke passed through a Cambridge filter that removed particulate matter was 3.4-fold more active in ROS production compared with unfiltered smoke, suggesting that most of the oxidative effects are produced by the gaseous phase. Alveolar macrophages obtained from habitual MJ smokers displayed low levels of glutathione compared with macrophages from nonsmokers.”

Source: https://www.ncbi.nlm.nih.gov/pubmed/10340948

Oxidative Stress Produced by Marijuana Smoke An Adverse Effect Enhanced by Cannabinoids

“Brief exposure to smoke from 3.95% MJ cigarettes stimulated the formation of reactive oxygen species (ROS) by 80% over control levels and lowered intracellular glutathione levels by 81%.”

Source: https://www.atsjournals.org/doi/full/10.1165/ajrcmb.20.6.3424

Differential transcriptional profiles mediated by exposure to the annabinoids cannabidiol and Δ9‐tetrahydrocannabinol in BV‐2 microglial cells

“CBD‐specific gene expression profile showed changes associated with oxidative stress and glutathione depletion”

Source: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1476-5381.2011.01461.x

Vapors Produced by Electronic Cigarettes and E-Juices with Flavorings Induce Toxicity, Oxidative Stress, and Inflammatory Response in Lung Epithelial Cells and in Mouse Lung

“By exposing wild-type (C57BL/6J) mice to e-cig aerosols, we examined the effect of short-term (3 days) exposure to e-cig aerosols on aspects of lung inflammation, oxidative stress, and redox physiology by measuring changes in glutathione levels.”

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319729/

Glutathione is the key food to cellular life and energy.